Brazilian Journal of Pathology and Laboratory Medicine

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Vol 54, Issue 5

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

Is muscle biopsy still necessary for the diagnosis of mitochondrial disease?

Article Type, Editorial, Issue, Vol 54, Issue 5 /

Paulo Victor S. Souza; Wladimir B. V. R. Pinto; Acary S. B. OliveiraJ. Bras. Patol. Med. Lab. 2018;54(5):272DOI:10.5935/1676-2444.20180046 ABSTRACT Mitochondria are essential organelles for human life and play a central role in diverse cellular processes such as energy production, reactive oxygen species, biosynthetic intermediates, autophagy, amino acid and fatty acid synthesis and degradation, heme synthesis, […]

Is muscle biopsy still necessary for the diagnosis of mitochondrial disease? Read More »

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

Aspartate aminotransferase to platelet ratio index (APRI) for differentiation of primary and secondary infection by dengue virus

Article Type, Issue, Original Article, Vol 54, Issue 5 /

Suellen R. Martins, Melina B. Pinheiro, Luci Maria S. Dusse, Ana Paula L. Mota, Patrícia N. AlpoimJ. Bras. Patol. Med. Lab. 2018;54(5):273-278DOI:10.5935/1676-2444.20180047 RESUMO INTRODUÇÃO: A infecção pelo vírus da dengue (DENV) é considerada um grande problema de saúde pública nos países tropicais. A indisponibilidade de testes sorológicos em centros de saúde pública pode afetar negativamente o

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FTIR of β-LAP, DpCS and the β-LAP/DpCS conjugate

Evaluation of acute toxicity of β-lapachone associated with chitosan as a cytoprotective agent

Article Type, Issue, Original Article, Vol 54, Issue 5 /

Maria Eduarda F. A. G. Oliveira; Érika Cristina G. M. Silva; Celso A. Câmara; Ivone Antônia de Souza; Rosa Valéria S. AmorimJ. Bras. Patol. Med. Lab. 2018;54(5):279-287DOI:10.5935/1676-2444.20180048 RESUMO INTRODUÇÃO: A β-lapachona (β-LAP), um potente agente antitumoral, tem uso terapêutico limitado devido a sua baixa solubilidade e elevada toxicidade. Uma possível estratégia para contornar esses inconvenientes pode

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Perceptual map via the main components for the variables

Molecular association of pathogenicity and resistance to multiple antimicrobials in Acinetobacter baumannii strains recovered from patients with diverse infectious diseases

Article Type, Issue, Original Article, Vol 54, Issue 5 /

Rafaela O. França; Priscila S. Costa; Guilherme Luiz Milanez; Maria Rosa Q. Bomfim; Ricardo Gonçalves; Luiz M. Farias; Vandack Nobre; Simone G. SantosJ. Bras. Patol. Med. Lab. 2018;54(5):288-295DOI:10.5935/1676-2444.20180049 RESUMO INTRODUÇÃO: O sucesso das infecções por Acinetobacter baumannii pode ser atribuído a seus vários fatores de virulência e a mecanismos de resistência a antimicrobianos.OBJETIVO: Avaliar a presença e a correlação

Molecular association of pathogenicity and resistance to multiple antimicrobials in Acinetobacter baumannii strains recovered from patients with diverse infectious diseases Read More »

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-

Article Type, Issue, Original Article, Vol 54, Issue 5 /

Tumores de mama que superexpressam HER2 estão associados ao fenótipo de células-tronco tumorais CD44+/CD24 Iris Rabinovich1,2; Lúcia de Noronha1; Ana Paula M. Sebastião2; Rubens S. Lima2; Cícero A. Urban3; Eduardo Schunemann Jr.2; Selene Elífio-Esposito1; Cleverton C. Spautz2; Andréa N. Moreno-Amaral1 1. Pontifícia Universidade Católica do Paraná (PUCPR), Paraná, Brazil2. Universidade Federal do Paraná (UFPR), Paraná,

HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- Read More »

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

Evaluation of the accuracy of frozen section in different anatomical sites

Article Type, Issue, Original Article, Vol 54, Issue 5 /

Rafael P. Santana; Nivaldo S. Morais; Yves Renan S. Samary; Artur Lício R. Bezerra; Daniela M. TakanoJ. Bras. Patol. Med. Lab. 2018;54(5):319-324DOI:10.5935/1676-2444.20180053 RESUMO INTRODUÇÃO: O exame intraoperatório por congelação (EIC) visa avaliar histológica e intraoperatoriamente um pequeno fragmento de tecido ou órgão lesado no qual haja dúvida diagnóstica. Entre as indicações do EIC estão a determinação

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Ragged red fibers, hallmark of mitochondrial disorders, in modified Gomori

Quantitation of muscle pathology abnormalities in 18 patients with mitochondrial disorders

Article Type, Issue, Original Article, Vol 54, Issue 5 /

João A. Kouyoumdjian; Carla Renata Graça; Vanessa Fernanda M. FerreiraJ. Bras. Patol. Med. Lab. 2018;54(5):325-332DOI:10.5935/1676-2444.20180054 RESUMO INTRODUÇÃO: Desordens mitocondriais são usualmente caracterizadas por: 1. acúmulo de mitocôndria nas fibras musculares que aparecem como fibras vermelhas rasgadas (FVR) ou azuis rasgadas quando coradas, respectivamente, pelo tricrômio modificado de Gomori ou pelo succinato desidrogenase (SDH+); 2. ausência de

Quantitation of muscle pathology abnormalities in 18 patients with mitochondrial disorders Read More »

Images of the patient at 10 years of age showing diffuse and irregular alopecia with hair rupture at different levels, giving an appearance of hypotrichosis (A and B)

Description of clinical aspects and microscopy of the hair shaft of a carrier of familial monilethrix

Article Type, Issue, Vol 54, Issue 5 /

Maria Angélica T. Ferreira; João Francisco O. Gonzales; Bruna L. Diniz; Maiara A. Floriani; Ana Elisa K. Bau; Rosana C. M. Rosa; Rafael Fabiano M. Rosa; Paulo Ricardo G. ZenJ. Bras. Patol. Med. Lab. 2018;54(5):333-335DOI:10.5935/1676-2444.20180055 ABSTRACT Monilethrix is a genetic condition that affects the hair shaft. We describe a family with this disease, focusing on

Description of clinical aspects and microscopy of the hair shaft of a carrier of familial monilethrix Read More »

The cysts were lined by cubic or flat epithelia, sometimes with hobnail cells

Cystic nephroma and DICER1 mutations: report of a hitherto unreported mutation

Article Type, Issue, Original Article, Vol 54, Issue 5 /

Rui Caetano Oliveira; Mónica Jerónimo; Alexandra Paúl; Carol Marinho; Fátima HeitorJ. Bras. Patol. Med. Lab. 2018;54(5):336-339DOI:10.5935/1676-2444.20180056 ABSTRACT Paediatric cystic nephroma is a neoplasm of uncertain pathogenesis characterized by a multilocular architecture that develops in children. Some cases may be sporadic, and others may present a familial association, together with other neoplasms, as part of a

Cystic nephroma and DICER1 mutations: report of a hitherto unreported mutation Read More »

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

Yellow fever: laboratorial diagnosis and clinical manifestations

Article Type, Issue, Review Article, Vol 54, Issue 5 /

Analúcia R. Xavier; Gabriela S. Freitas; Caroline F. Santos; Werlley A. Januzzi; Gilmar S. Lacerda; Edimilson R. M. Carvalho; Salim KanaanJ. Bras. Patol. Med. Lab. 2018;54(5):296-305DOI:10.5935/1676-2444.20180050 ABSTRACT Yellow fever is an infectious disease of acute evolution, initially non-contagious, transmitted by a ribonucleic acid (RNA) virus that belongs to the Flaviviridae family. In the period from December 2016

Yellow fever: laboratorial diagnosis and clinical manifestations Read More »