Brazilian Journal of Pathology and Laboratory Medicine

Please contact: journal@jbpml.org.br

Vol 53, Issue 1

Performance validation of western blot for anti-HIV antibody detection in blood samples collected on filter paper (DBS)

Marcia J. Castejon; Rosemeire Yamashiro; Carmem Aparecida F. Oliveira; Maria Amélia S. M. VerasJ. Bras. Patol. Med. Lab. 2017;53(1):5-12DOI: 10.5935/1676-2444.20170002 ABSTRACT INTRODUCTION: For conducting field studies on human immunodeficiency virus (HIV) serodiagnosis, the use of samples collected on filter paper [dried blood spot (DBS)] is profitable owing to the simplicity in handling and delivering them. Because

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Molecular technique for detection and identification of Helicobacter pylori in clinical specimens: a comparison with the classical diagnostic method

Jéssica C. Nevoa; Roger Luiz Rodrigues; Gabriela L. Menezes; Andressa R. Lopes; Hemelly F. Nascimento; Silvana B. Santiago; Marcos L. Morelli; Monica S. BarbosaJ. Bras. Patol. Med. Lab. 2017;53(1):13-19DOI: 10.5935/1676-2444.20170003 ABSTRACT INTRODUCTION: Helicobacter pylori is a bacterium found in human epithelial cells of the gastrointestinal tract. Its infection is related to different diseases, such as chronic

Molecular technique for detection and identification of Helicobacter pylori in clinical specimens: a comparison with the classical diagnostic method Read More »

The detection of Bence Jones protein in urine by the heat test helps in diagnosis of multiple myeloma?

Ana Paula O. Tomaz; Maristela de Paiva; José Ederaldo Q. Telles; Angela Maria de Souza; Laura Lucia CogoJ. Bras. Patol. Med. Lab. 2017;53(1):20-23DOI: 10.5935/1676-2444.20170006 ABSTRACT INTRODUCTION: Multiple myeloma (MM) is a hematologic malignancy caused by the intense indiscriminate proliferation of plasma cells in the bone marrow. In view of clinical suspicion of MM, clinic laboratory tests

The detection of Bence Jones protein in urine by the heat test helps in diagnosis of multiple myeloma? Read More »

The frequency of βS-globin haplotypes in the state of Paraná, Brazil, and clinical manifestations of sickle cell anemia

Alexandra M. Watanabe; Mara A. D. Pianovski; Luana Lenzi; Rubens CatJ. Bras. Patol. Med. Lab. 2017;53(1):24-30DOI: 10.5935/1676-2444.20170007 ABSTRACT INTRODUCTION: Haplotypes in the βS-globin cluster are named according to their geographical origin as Central African Republic (CAR), Benin (BEN), Senegal (SEN), Cameroon (CAM) and Arab-Indian. They are considered to have influence on the diversity of clinical manifestations

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Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

Evaluation of cytokines in type 1 diabetes patients with and without retinopathy

Jéssica F. Cardoso; Karina B. Gomes; Ana Paula Fernandes; Caroline P. DominguetiJ. Bras. Patol. Med. Lab. 2017;53(1):31-37DOI: 10.5935/1676-2444.20170001 ABSTRACT INTRODUCTION: Diabetes mellitus is one of the greatest public health problems in the world; the numerous complications of this disease are the focus of great concern, as they are related to high morbidity and mortality. Among the complications of

Evaluation of cytokines in type 1 diabetes patients with and without retinopathy Read More »

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

The measurement of serum osmolality and its application to clinical practice and laboratory: literature review

Daniel K. Faria; Maria Elizabete Mendes; Nairo M. SumitaJ. Bras. Patol. Med. Lab. 2017;53(1):38-45DOI: 10.5935/1676-2444.20170008 ABSTRACT INTRODUCTION: Serum osmolality is an essential laboratory parameter to understand several clinical disorders such as electrolyte disturbances, exogenous intoxication and hydration status.OBJECTIVE: This study aims to update knowledge about the osmolality examination through research papers published to date.MATERIALS AND METHODS: The survey

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Tissue immunostaining of growth, pro- and anti-apoptotic biomarkers in myocardial samples from newborns with hypoxic injury

Francisco Cesar Pabis; Mona Adalgisa Simões; Renata R. Sakiyama; Fernando Y. R. Sakiyama; Rafael M. Kayano; Seigo Nagashima; Lúcia de NoronhaJ. Bras. Patol. Med. Lab. 2017;53(1):46-52DOI: 10.5935/1676-2444.20170009 ABSTRACT INTRODUCTION: Despite the importance of cardiovascular diseases to population health, there is limited knowledge about how neonatal hypoxia, related or not with prematurity, may cause cell injury to

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Predominant overexpression of CD25/FOXP3, IFN-γ, and suppressive cytokines in high-grade lesion samples infected with human papillomavirus

Camila M. Bonin; Cacilda T. J. Padovani; Alda Maria T. Ferreira; Leandro S. Ávila; Ana Paula Machado; Thiago T. M. Prata; Carlos Eurico S. Fernandes; Inês Aparecida TozettiJ. Bras. Patol. Med. Lab. 2017;53(1):53-60DOI: 10.5935/1676-2444.20170004 ABSTRACT INTRODUCTION: Human papillomavirus (HPV) persistent infection is the leading cause of cervical cancer and its precursor lesions, and the inappropriate immune

Predominant overexpression of CD25/FOXP3, IFN-γ, and suppressive cytokines in high-grade lesion samples infected with human papillomavirus Read More »

Acute lymphoblastic leukemia: primary bone manifestation with hypercalcemia in a child

Cristiano C. Oliveira; Luan Kucko; Eric J. Hirama; Helena M. Guerra; Simone A. Terra; Lied M. Santiago; Manuella P. Segredo; Ligia Niero-Melo; Maria Aparecida C. DominguesJ. Bras. Patol. Med. Lab. 2017;53(1):61-64DOI: 10.5935/1676-2444.20170010 ABSTRACT Primary bone manifestation associated with hypercalcemia is an infrequent presentation of acute lymphoblastic leukemia (ALL) in children. An 8-year-old girl was admitted

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