Vol 51, Issue 6 – Brazilian Journal of Pathology and Laboratory Medicine

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

JBPML puts its commitment to the care of safety in the laboratory

Article Type, Editorial, Issue, Vol 51, Issue 6 / wadmin

Silvana Maria Eloi-SantosJ. Bras. Patol. Med. Lab. 2015;51(6):358DOI: 10.5935/1676-2444.20150056 ABSTRACT In 2009, the US Food and Drug Administration (FDA) approved the Clinical and Laboratory Standards Institute ([CLSI] – formerly NCCLS) consensus standard for auto verification of clinical laboratory test results(1). That guideline provides a general framework that allows clinical laboratories to propose, implement, validate, and […]

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Comparison between immunofixation and electrophoresis for the early detection of relapsed multiple myeloma

Article Type, Issue, Laboratory Medicine, Vol 51, Issue 6 / wadmin

Marta Helena C. Aita; Luiz Claudio Arantes; Bruno C. Aita; José Edson P. SilvaJ. Bras. Patol. Med. Lab. 2015;51(6):359-368DOI: 10.5935/1676-2444.20150057 ABSTRACT INTRODUCTION: Multiple myeloma (MM) is an incurable progressive hematological neoplasia characterized by heterogeneous evolution and by relapses after therapy.OBJECTIVE: Compare the effectiveness of serum immunofixation (SIF) and electrophoresis (SPE) techniques in the detection of relapses in

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Autoverification of the automated blood cell counter (CBC) in a reference laboratory in Bogota, Colombia

Article Type, Issue, Laboratory Medicine, Vol 51, Issue 6 / wadmin

Oscar Martinez-Nieto; Adriana Lozano-Gaitán; Paola Beltrán-Diaz; Ivan Leonardo Mojica-Figueroa; Olga Lucia Morales-Reyes; Mario A. Isaza-RugetJ. Bras. Patol. Med. Lab. 2015;51(6):369-375DOI: 10.5935/1676-2444.20150058 ABSTRACT INTRODUCTION: The clinical laboratory is part of the group of actors in health systems that are under increasing pressure by users and administrators to increase their productivity in order to respond efficiently to the

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Cerebrospinal fluid biomarkers for the differential diagnosis of Alzheimer’s disease

Article Type, Issue, Laboratory Medicine, Vol 51, Issue 6 / wadmin

Carolina A. Magalhães; Micheli Figueiró; Vanessa G. Fraga; Elvis C. Mateo; André A. S. F. Toledo; Maria das Graças Carvalho; Paulo Caramelli; Karina B. GomesJ. Bras. Patol. Med. Lab. 2015;51(6):376-382DOI: 10.5935/1676-2444.20150059 ABSTRACT INTRODUCTION: Several studies have been conducted in order to validate cerebrospinal fluid biomarkers for the diagnosis of Alzheimer’s disease (AD), aiming primarily to facilitate

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$Quantification of cardiac and oxidative stress makers in different experimental groups A) total CK; B) CK-MB; C) TBARS. Data are expressed as mean ± SEM; * p < 0.05 when compared to group without MI. CK: creatine kinase; CK-MB: creatine-kinase MB fraction; TBARS: thiobarbituric acid reactive substances; SEM: standard error of the mean; MI: myocardial infarction.$

Use of ischemia modified albumin for the diagnosis of myocardial infarction

Article Type, Issue, Laboratory Medicine, Vol 51, Issue 6 / wadmin

Nariélle F. Bonorino; Adroaldo Lunardelli; Jarbas R. OliveiraJ. Bras. Patol. Med. Lab. 2015;51(6):383-388DOI: 10.5935/1676-2444.20150060 ABSTRACT INTRODUCTION: Literature reports addressing ischemia modified albumin (IMA) as a good marker for the early diagnosis of myocardial ischemia through albumin cobalt binding (ACB) test, that is before myocardial infarction (MI) occurs.OBJECTIVE: To evaluate the IMA plasmatic levels in infarcted patients, in

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Recommendations for quality assurance in multiparametric flow cytometry: first consensus of the Brazilian Group of Flow Cytometry (GBCFLUX)

Article Type, Issue, Pathology, Vol 51, Issue 6 / wadmin

Rodolfo P. Correia; Ana Carolina A. Bortolucci; Annelise C. W. Lopes; Alex F. Sandes; Ana Paula de Azambuja; Marta A. Viana; Maria M. Sales; Mihoko Yamamoto; Nydia S. Bacal (on behalf of GBCFLUX)J. Bras. Patol. Med. Lab. 2015;51(6):389-396DOI: 10.5935/1676-2444.20150061 ABSTRACT The Brazilian Group of Flow Cytometry (Grupo Brasileiro de Citometria de Fluxo [GBCFLUX]), founded on

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Clinical, histomorphological, and therapeutic prognostic factors in patients with invasive triple-negative breast cancer

Article Type, Issue, Pathology, Vol 51, Issue 6 / wadmin

Camila M. Lopes; Mário R. Montemor Netto; Fábio P. Mansani; Rebecca S. M. Stival; Maíra R. Cassapula; Tainá Fernanda B. OliveiraJ. Bras. Patol. Med. Lab. 2015;51(6):397-406DOI: 10.5935/1676-2444.20150062 ABSTRACT INTRODUCTION: Breast cancer is the most common visceral malignancy in women, the leading cause of cancer death among women worldwide. The triple negative subgroup has poor prognosis and

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Correlation and comparison of immunohistochemistry for HER2/neu, using the antibody SP3 and chromogenic in situ hybridization in breast carcinomas samples

Article Type, Issue, Pathology, Vol 51, Issue 6 / wadmin

Franciele F. Wolf; Giuliano S. Bublitz; Henrique R. FrigeriJ. Bras. Patol. Med. Lab. 2015;51(6):407-414DOI: 10.5935/1676-2444.20150063 ABSTRACT INTRODUCTION: Advances in the field of molecular biology have provided the differentiation of molecular subtypes of breast tumors, providing better prognosis and important tools for the treatment of patients with breast cancer. Among these subtypes, the changes in the human

Correlation and comparison of immunohistochemistry for HER2/neu, using the antibody SP3 and chromogenic in situ hybridization in breast carcinomas samples Read More »

SCC of the tongue Intense immunohistochemical expression of CD68 (A and B) and CD163 (C and D), showing compressive invasion pattern, with outlined infiltrating border adjacent to abundant inflammatory infiltrate (Panoramic Viewer, Advance). SCC: squamous cell carcinoma.

Immunohistochemical study of macrophages subpopulations associated with squamous cell carcinoma of the tongue, with and without metastasis

Article Type, Issue, Pathology, Vol 51, Issue 6 / wadmin

Natália G. Barbosa; Melka C. Sá; Leão P. Pinto; Roseana A. FreitasJ. Bras. Patol. Med. Lab. 2015;51(6):415-421DOI: 10.5935/1676-2444.20150064 ABSTRACT INTRODUCTION: Stromal cells interact with tumor cells and play an important role in cancer invasion and metastasis. Tumor-associated macrophages (TAMs) can exhibit M1 phenotype, important immune effector cells, or M2 phenotype, able to suppress the function of

Immunohistochemical study of macrophages subpopulations associated with squamous cell carcinoma of the tongue, with and without metastasis Read More »

Gross and microscopic examination: pathological findings of inflammatory myofibroblastic tumour

Inflammatory myofibroblastic tumour arising incidentally as a polypoid lesion in the gallbladder

Article Type, Issue, Pathology, Vol 51, Issue 6 / wadmin

Carlos Filipe C. Abrantes; Mário Rui Silva; Rui Caetano Oliveira; Catarina Eloy; Maria Augusta Cipriano; Lígia P. CastroJ. Bras. Patol. Med. Lab. 2015;51(6):422-426DOI: 10.5935/1676-2444.20150065 ABSTRACT Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm that usually originates from abdominal soft tissues. A female patient aged 50 years presented with a 1.2 cm gallbladder polyp. The

Inflammatory myofibroblastic tumour arising incidentally as a polypoid lesion in the gallbladder Read More »