Brazilian Journal of Pathology and Laboratory Medicine

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Tissue immunostaining of growth, pro- and anti-apoptotic biomarkers in myocardial samples from newborns with hypoxic injury

Article Type, Issue, Laboratory medicine, Vol 53, Issue 1 /

Francisco Cesar Pabis; Mona Adalgisa Simões; Renata R. Sakiyama; Fernando Y. R. Sakiyama; Rafael M. Kayano; Seigo Nagashima; Lúcia de NoronhaJ. Bras. Patol. Med. Lab. 2017;53(1):46-52DOI: 10.5935/1676-2444.20170009 ABSTRACT INTRODUCTION: Despite the importance of cardiovascular diseases to population health, there is limited knowledge about how neonatal hypoxia, related or not with prematurity, may cause cell injury to […]

Tissue immunostaining of growth, pro- and anti-apoptotic biomarkers in myocardial samples from newborns with hypoxic injury Read More »

Predominant overexpression of CD25/FOXP3, IFN-γ, and suppressive cytokines in high-grade lesion samples infected with human papillomavirus

Article Type, Issue, Laboratory medicine, Vol 53, Issue 1 /

Camila M. Bonin; Cacilda T. J. Padovani; Alda Maria T. Ferreira; Leandro S. Ávila; Ana Paula Machado; Thiago T. M. Prata; Carlos Eurico S. Fernandes; Inês Aparecida TozettiJ. Bras. Patol. Med. Lab. 2017;53(1):53-60DOI: 10.5935/1676-2444.20170004 ABSTRACT INTRODUCTION: Human papillomavirus (HPV) persistent infection is the leading cause of cervical cancer and its precursor lesions, and the inappropriate immune

Predominant overexpression of CD25/FOXP3, IFN-γ, and suppressive cytokines in high-grade lesion samples infected with human papillomavirus Read More »

Acute lymphoblastic leukemia: primary bone manifestation with hypercalcemia in a child

Article Type, Issue, Pathology, Vol 53, Issue 1 /

Cristiano C. Oliveira; Luan Kucko; Eric J. Hirama; Helena M. Guerra; Simone A. Terra; Lied M. Santiago; Manuella P. Segredo; Ligia Niero-Melo; Maria Aparecida C. DominguesJ. Bras. Patol. Med. Lab. 2017;53(1):61-64DOI: 10.5935/1676-2444.20170010 ABSTRACT Primary bone manifestation associated with hypercalcemia is an infrequent presentation of acute lymphoblastic leukemia (ALL) in children. An 8-year-old girl was admitted

Acute lymphoblastic leukemia: primary bone manifestation with hypercalcemia in a child Read More »

Applications of electron microscopy in health: the example of epidermolysis bullosa

Article Type, Issue, Pathology, Vol 53, Issue 1 /

Maiara A. Floriani; Ana Elisa K. Bau; Raquel P. Silva; Carla Graziadio; Luiza Emy Dorfman; Tatiana D. Zen; Rafael Fabiano M. Rosa; Paulo Ricardo G. ZenJ. Bras. Patol. Med. Lab. 2017;53(1):65-67DOI: 10.5935/1676-2444.20170011 ABSTRACT We report the case of a patient with dystrophic epidermolysis bullosa (DEB) diagnosed by transmission electron microscopy (TEM), emphasizing the applications and

Applications of electron microscopy in health: the example of epidermolysis bullosa Read More »

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

Diet and cancer

Article Type, Editorial, Issue, Vol 52, Issue 6 /

Adagmar AndrioloJ. Bras. Patol. Med. Lab. 2016;52(6):366DOI: 10.5935/1676-2444.20160059 Cancer is a complex group of diseases with numerous possible causes. These include genetic factors, eating habits, lifestyle, viral infections, exposure to different types of potentially mutagenic agents and radiation, among others. Although it represents an important group, cancers arising from inherited gene mutations correspond to a

Diet and cancer Read More »

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

Sepsis-associated organ dysfunction and increased supportive care are associated with high serum interleukin-6 levels

Article Type, Issue, Laboratory Medicine, Vol 52, Issue 6 /

Adriana Carta; Maria Gabriela de Lucca; Milton D. Pires; Suzana Margareth LoboJ. Bras. Patol. Med. Lab. 2016;52(6):367-373DOI: 10.5935/1676-2444.20160060 ABSTRACT INTRODUCTION: Detection of sepsis and septic shock is essential, since any delay in initiating a proper treatment is associated with a worse prognosis.OBJECTIVE: To evaluate levels of interleukin-6 (IL-6) early in the onset of the evolution of sepsis

Sepsis-associated organ dysfunction and increased supportive care are associated with high serum interleukin-6 levels Read More »

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

Analysis of laboratory tests results of patients submitted to a clinical screening program

Article Type, Issue, Laboratory Medicine, Vol 52, Issue 6 /

Raphaela M. Zapelini; Kaiser S. Koch; Geraldo César C. Althoff; Camila S. Duarte; Eloysa M. João; Sérgio Silveira Jr.J. Bras. Patol. Med. Lab. 2016;52(6):374-381DOI: 10.5935/1676-2444.20160061 ABSTRACT INTRODUCTION: There are not studies demonstrating the major changes in biochemical tests performed in screening programs.OBJECTIVE: Identify the results found in laboratory tests of patients submitted to medical check-up program, showing

Analysis of laboratory tests results of patients submitted to a clinical screening program Read More »

Presence of the of anti-factor VIII inhibitor antibody

Incidence of factor VIII inhibitory antibodies in patients with hemophilia A seen at HEMOCE, Ceará, Brazil

Article Type, Issue, Laboratory Medicine, Vol 52, Issue 6 /

Rosineide A. Carvalho; Paulo Henrique da Silva; Railson HennebergJ. Bras. Patol. Med. Lab. 2016;52(6):382-386DOI: 10.5935/1676-2444.20160056 ABSTRACT INTRODUCTION: Hemophilia A is an inherited disease caused by a deficiency of factor VIII, which results from a genetic inheritance located on the X chromosome. During treatment of patients with this disorder, factor VIII inhibitors may be present, which are

Incidence of factor VIII inhibitory antibodies in patients with hemophilia A seen at HEMOCE, Ceará, Brazil Read More »

Evaluation of TP53 Gene Expression in Patients with Childhood Cancer in Northeast Santa Catarina, Brazil

Clinical correlation between the Point-of-care testing method and the traditional clinical laboratory diagnosis in the measure of the lipid profile in patients seen in medical offices

Article Type, Issue, Laboratory Medicine, Vol 52, Issue 6 /

Hermes T. Xavier; Rogerio M. Ruiz; Luiz Kencis Jr.; Giovanni Melone; William Costa; Raffael Francisco Fraga; Luciano Wajman; Marcio Krakauer; Marileia ScarteziniJ. Bras. Patol. Med. Lab. 2016;52(6):387-390DOI: 10.5935/1676-2444.20160057 ABSTRACT INTRODUCTION: Elevated plasma levels of lipids are considered the main modifiable risk factor for the cardiovascular disease. The Point-of-care testing (POCT) method provides quick results and allows

Clinical correlation between the Point-of-care testing method and the traditional clinical laboratory diagnosis in the measure of the lipid profile in patients seen in medical offices Read More »

Fetal ultrasound performed at 16 weeks of gestation showing the cystic hygroma

Use of the fluid obtained by puncture of cystic hygroma: an alternative method for fetal karyotyping

Article Type, Issue, Laboratory Medicine, Vol 52, Issue 6 /

Maiara A. Floriani; Luiza E. Dorfman; Dayane B. Koshiyama; Tatiana D. Zen; Jorge Alberto B. Telles; André C. Cunha; Paulo Ricardo G. Zen; Rafael Fabiano M. RosaJ. Bras. Patol. Med. Lab. 2016;52(6):391-392DOI: 10.5935/1676-2444.20160062 ABSTRACT The aim of our study aim was to report the case of a fetus with Turner syndrome (TS) diagnosed by karyotype

Use of the fluid obtained by puncture of cystic hygroma: an alternative method for fetal karyotyping Read More »