Amna Ali Naser
Department of Biology, College of science, University of Babylon, Babylon, Iraq
Shaimaa Jassim AlSultany
Department of Biology, College of science, University of Babylon, Babylon, Iraq
ABSTRACT
This study examined pregnancy-related urinary tract infections (UTIs) and their bacteria. This study also examined how urinary tract infections affect blood and immunological indicators like IL-10 and IL-18R1. Patients and Methods: -This study involved the collection of 44 blood and urine samples from pregnant women between the ages of 18 and 41 who had urinary tract infections. The samples were obtained from a children's hospital in Al Samawa city. Additionally, 44 samples were taken from healthy nonpregnant women without urinary tract infections or chronic diseases. These samples were used as a control group, and the women were between the ages of 18 and 41. The urine specimens were analyzed and cultured and then identified by different media, biochemical tests and vitek2, along with laboratory blood tests, to identify blood variables and measure certain immune variables. Enzyme-linked immune sorbent assay (ELISA) was used to quantify the levels of IL-10 and IL-18R1. Result: - all urine samples taken from healthy nonpregnant women showed no bacterial growth. Our investigation included certain strains of bacteria, such as Escherichia coli (16), Pseudomonas aeruginosa (6), Klebsiella pneumoniae (2), Staphylococcus aureus (10), and Enterobacter faecalis (10). IL-10 levels were greatest in pregnant women infected with Escherichia coli and Klebsiella pneumoniae, followed by pregnant women infected with Pseudomonas aeruginosa, and lowest in nonpregnant women .IL-18R1 levels were greatest in pregnant women infected with Klebsiella pneumoniae, followed by those infected with Staphylococcus aureus and Escherichia coli, and lowest in pregnant women infected with Enterobacter faecalis. Conclusion: -This research revealed that pregnant women with K. pneumoniae, P. aeruginosa, and E. faecalis had increased IL-10 and IL-18R1 levels, while nonpregnant women had decreased IL-10 and IL-18R1 levels. These differences were statistically significant.
Keywords: Gram-Negative; Gram-Positive; IL10; IL18 Receptor 1.
