Gabriela Fialho
Department of Phamaceutical Sciences, UNIFESP-Federal University of São Paulo, Diadema, São Paulo, Brazil
Fernando Jablonka
Discipline of Clinical Analysis, Department of Pathology, CUFMABC-Centro Universitário Faculdade de Medicina do ABC – Fundação do ABC, Santo André, São Paulo, Brazil
Gerson Salay
Discipline of Clinical Analysis, Department of Pathology, CUFMABC-Centro Universitário Faculdade de Medicina do ABC – Fundação do ABC, Santo André, São Paulo, Brazil
Thaís Gascón
Discipline of Clinical Analysis, Department of Pathology, CUFMABC-Centro Universitário Faculdade de Medicina do ABC – Fundação do ABC, Santo André, São Paulo, Brazil
Samantha Carvalho
Discipline of Clinical Analysis, Department of Pathology, CUFMABC-Centro Universitário Faculdade de Medicina do ABC – Fundação do ABC, Santo André, São Paulo, Brazil
Beatriz Alves
Discipline of Clinical Analysis, Department of Pathology, CUFMABC-Centro Universitário Faculdade de Medicina do ABC – Fundação do ABC, Santo André, São Paulo, Brazil
Glaucia Veiga
Discipline of Clinical Analysis, Department of Pathology, CUFMABC-Centro Universitário Faculdade de Medicina do ABC – Fundação do ABC, Santo André, São Paulo, Brazil
Neif Murad
Discipline of Clinical Analysis, Department of Pathology, CUFMABC-Centro Universitário Faculdade de Medicina do ABC – Fundação do ABC, Santo André, São Paulo, Brazil
Edimar Cristiano Pereira
Department of Phamaceutical Sciences, UNIFESP-Federal University of São Paulo, Diadema, São Paulo, Brazil
Araceli Aparecida Hastreiter
Department of Phamaceutical Sciences, UNIFESP-Federal University of São Paulo, Diadema, São Paulo, Brazil
Fernando Luiz Affonso Fonseca
Department of Phamaceutical Sciences, UNIFESP-Federal University of São Paulo, Diadema, São Paulo, Brazil
ABSTRACT
This study investigated the correlation between absolute monocyte count and HDL levels, aiming to understand their role as a risk indicator for cardiovascular diseases (CVD) in people living with HIV (PLHIV). The research involved a search for scientific articles in the PubMed and EBSCO databases using the PICOT strategy (Population, Intervention, Comparison, Outcome, and Time), along with a table summarizing key information from selected articles based on specific criteria. This was followed by a detailed discussion correlating the findings. Results indicated that the HDL/Monocyte ratio has potential as a CVD marker due to its association with the pathogenesis of atherosclerosis, despite limited studies validating its use in PLHIV. The observed correlation between HDL levels and inflammatory markers, especially MCP-1, reinforces its promising potential for future investigations. This is supported by its potential for clinical management, given that it is a simple, cost-effective method. However, further targeted studies are necessary to investigate the applicability and sensitivity of this marker in PLHIV. The study also proposed exploring complementary strategies to antiretroviral therapy (ART) for controlling chronic inflammation from HIV infection, preventing other related diseases in PLHIV.
Keywords: Good Health and Well Being; HIV; Cardiovascular Disease; HDL; Monocyte.
