Qaisar Mashan Abd
Department of Chemistry, College of Education of Pure Science, University of Tikrit, Iraq
ABSTRACT
Background: Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder characterized by bradykinesia, rigidity, and tremor. Laboratory investigation of neurotransmitters, cytokines, and oxidative stress markers may provide important insights into its underlying pathophysiology. Methods: This case–control study included 30 patients with clinically diagnosed PD (aged 45–65 years) recruited between May and December 2024 from the Medical City, and 20 age-matched healthy controls. Following venous blood collection (5 mL), serum samples were obtained by centrifugation and analyzed for acetylcholinesterase activity, dopamine concentration, interleukin-6 (IL-6), and antioxidant biomarkers including glutathione (GSH) and malondialdehyde (MDA). Results: Compared with healthy controls, patients with PD showed significantly elevated serum acetylcholinesterase, IL-6, and MDA levels (p < 0.05). In contrast, dopamine and GSH concentrations were significantly reduced in PD patients (p < 0.05). Conclusion: Alterations in acetylcholinesterase, dopamine, IL-6, and antioxidant markers highlight the role of both neuroinflammation and oxidative stress in the pathology of PD. These biomarkers may serve as potential laboratory indicators for disease progression and therapeutic monitoring.
Keywords: Parkinson’s Disease, Acetylcholinesterase, Dopamine, IL-6, Oxidative Stress, Biomarkers.
