Zainab S. Hassab
Osol AL-Elm University College, Baghdad, Iraq
Adil N. Hami
Ibn Al-Baladi hospital Center for hereditary blood disease, Iraq
Zahraa A. Hussein
College of science for women, University of Baghdad, Iraq
Saadia O. Mohammed
AL-Esraa University, Iraq
Aya A. Saleem
College of science for women, University of Baghdad, Iraq
ABSTRACT
Background: β-TM is most hazardous among the other types of disorder in our country. Iron overload monitor are necessary for the survival of these patients. Iron excess causes immune deficiency and major organs dysfunction due to hemosiderosis. Study Aims: It designs to evaluate immunodeficiency in β-TM patients. Materials and Methods: The study was carried out between November 2022 and February 2023. The samples included 120 subjects. The samples involved the non-splenectomy, splenectomy, modern infection, and control. IgG, IgA, IgM, iron overload (ferritin), GPT, GOT, and TSB were estimated for patients. Results: The findings recorded a significant rise in serum IgG, IgA, and IgM and a decline in C3, and C4. High levels of immunoglobulins and iron overload in splenectomy than non-splenectomy. This may be due to the pressure on the other secondary lymphoid organs to compensate the deficiency. The results showed a positive correlation between IgA and a negative correlation of C4 with each of the serum iron overload and liver functions assays studies. Also, it observed a positive association between IgG and each of the GPT and GOT. Conclusions: Immunoglobulin increasing, complement consumption and iron overload elevating may be a sign of immunodeficiency in β-TM patients. Therefore, the present study suggested delaying splenectomy to prolong their survival.
Keywords: β-TM; Immunodeficiency; Iron Overload; Splenectomy.
