Sajid Khalil Mahmmod
Department of chemistry, College of Education, University of Samarra, Salahaldeen, Iraq
Malath Khalaf Rasheed
Department of chemistry, College of Education, University of Samarra, Salahaldeen, Iraq
ABSTRACT
Objective: This study aimed to synthesize and characterize Schiff base nanocomposites using ZnO and TiO2 nanoparticles for potential clinical applications in diagnosing and treating infectious diseases and liver function disorders. Methods: Schiff bases (SA1-SA5) were synthesized from 4-aminoantipyrine and various carboxaldehydes. Characterization was performed using melting point analysis, Fourier-transform infrared spectroscopy (FTIR), and proton nuclear magnetic resonance (HNMR). Nanocomposites were then prepared by doping Schiff bases with 20% ZnO and TiO2 nanoparticles, utilizing ultrasound irradiation for enhanced integration. X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM) were employed to analyze the nanocrystal structures and morphologies. Results: The synthesized nanocomposites demonstrated significant antibacterial activity against Staphylococcus aureus and Escherichia coli, and antifungal activity against Candida albicans, indicating their potential for treating infections. Additionally, the compounds were evaluated for their effects on alkaline phosphatase activity in models of liver dysfunction. The compounds showed promising results in modulating enzyme activity, suggesting potential applications in diagnosing and monitoring liver diseases. Conclusion: The Schiff base nanocomposites prepared with ZnO and TiO2 nanoparticles show significant potential in pathological diagnostics and as therapeutic agents. Their ability to inhibit microbial growth and modulate enzyme activity in liver disease models highlights their utility in clinical pathology, warranting further investigation for medical applications.
Keywords: 4-aminoantipyrine, Schiff base, Zinc oxide Nanocomposites, Titanium Dioxide Nanocomposites, alkaline phosphatase enzyme.
